2019年3月7日，据欧盟食品安全局（EFSA）消息，应欧盟委员会要求，欧盟动物饲料添加剂和产品（FEEDAP）研究小组被要求就Actisaf® Sc47作为奶牛、育肥牛、断奶仔猪和母猪的动物技术添加剂的安全性和有效性发表科学意见。

 

　　经过评估，FEEDAP小组得出结论认为，由于添加剂Actisaf®Sc47仅由活性剂组成，所以对目标动物和环境等是安全的。该添加剂有可能对断奶仔猪和母猪有效，但不确定对奶牛和牛育肥的有效性。

 

　　Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed （FEEDAP） was asked to deliver a scientific opinion on the safety and efficacy of Actisaf? Sc47 for dairy cows, cattle for fattening, weaned piglets and sows when used as a zootechnical additive. Actisaf® Sc47 consists of viable cells of a strain Saccharomyces cerevisiae and is marketed in three formulations. The FEEDAP Panel considers that the three available formulations are equivalent when used to deliver the same dose of the microorganism in feed. The active agent fulfils the requirements of the qualified presumption of safety approach to the assessment of safety. Since the additive is composed of the active agent only, Actisaf? Sc47 is also presumed safe for the target animals, consumers of products derived from treated animals and the environment.Actisaf? Sc47 is not a skin irritant. In the absence of data, no conclusions can be drawn on the eye irritancy and dermal sensitisation potential of the additive. Inhalation exposure is unlikely. The additive has the potential to be efficacious in weaned piglets and sows to have benefits in piglets at the recommended dose of 5 × 109 CFU/kg feed. Insufficient evidence was provided to conclude on the efficacy of the additive in dairy cows and cattle for fattening.