2019年11月6日，据欧盟食品安全局（EFSA）消息，应欧盟委员会要求，欧盟动物饲料添加剂和产品（FEEDAP）研究小组被要求就大肠杆菌（Escherichia coli）菌株CGMCC 11473发酵产生的L-苏氨酸（L‐threonine）作为所有动物物种营养添加剂的安全性发布科学意见。

 

　　经过评估， FEEDAP研究小组认为，该种添加剂对所有动物物种、消费者和环境都是安全的。对于该添加剂对皮肤和眼睛是否存在刺激性或是否会导致皮肤过敏，专家小组无法得出结论。

 

　　部分原文报道如下：

 

　　The l‐threonine under assessment is produced by fermentation with a genetically modified strain of Escherichia coli and it is intended to be used as a nutritional additive for all animal species. In 2017 the Panel on Additives and products or Substances used in Animal Feed （FEEDAP） of EFSA issued an opinion on the safety and efficacy of the product. In that assessment, the Panel could not conclude on the safety of the additive for the target species, consumers and the environment due to the lack of data regarding the characterisation of the production strain and the resulting product. The applicant provided additional data on the identity of the production strain, the genetic modification, the susceptibility to antibiotics and the absence of cells and recombinant DNA of the production strain in the final product. The recipient strain is safe and the genetic modification does not raise concerns. Moreover, viable cells or DNA of the production strain were not detected in the final product. With this new information the FEEDAP Panel concluded that l‐threonine produced by E. coli CGMCC 11473 is safe for the all animal species, the consumers and the environment. The FEEDAP Panel could not conclude on the potential of the additive to be irritant to skin and eyes or on the skin sensitisation potential. It was concluded that there is a risk of exposure to endotoxins by inhalation for persons handling the additive.