2019年5月3日，据欧盟食品安全局（EFSA）消息，应欧盟委员会的要求，欧盟动物饲料添加剂和产品（FEEDAP）研究小组就大肠杆菌NITE BP‐02351发酵产生的L-亮氨酸（L-leucine）作为所有动物品种饲料和饮用水的营养添加剂发表科学意见。
经过评估，评估小组认为当用作所有动物物种的调味化合物时，在25mg/Kg的建议使用水平下是安全的。在建议的使用条件下，这种添加剂被认为是有效的饲料调味化合物。
部分原文报道如下：
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed （FEEDAP） was asked to deliver a scientific opinion on l‐leucine produced by fermentation with Escherichia coli NITE BP‐02351 when used as nutritional additive or as feed flavouring compound in feed and water for drinking for all animal species. The product under assessment is l‐leucine produced by fermentation with a genetically modified strain of E. coli （NITE BP‐02351）。 The production strain and its recombinant DNA were not detected in the final products. l‐Leucine, manufactured by fermentation with E. coli NITE BP‐02351, does not give rise to any safety concern to the production strain. The use of l‐leucine produced with E. coli NITE BP‐02351 is safe for the target species when used to supplement the diet in appropriate amounts. It is safe at the proposed use level of 25 mg/kg when used as flavouring compound for all animal species. The use of l‐leucine produced by fermentation with E. coli NITE BP‐02351 in animal nutrition raises no safety concerns for consumers of animal products. The additive is not irritating to the skin or eyes and is not a skin sensitiser.
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